Each 1000gm Powder contains:
Potassium Clavulenate 8%
(As 4% Activity)
Water Soluble Powder
AMOXYCILLIN is semisynthetic antibiotic with a broad spectrum of bacterial activity against many gram-positive and gram-negative micro-organasims. Amoxicillin is however, usceptible to degradation by B-lactamases and therefore, the spectrum of activity does not include organisms which produce these enzyme. CLAVULANTIC ACID is a B-lactam is structurally related to the pencillins, which possesses the ability to interactive a wide range of B-lactamase enzymes commonly found in micro-orgnasims important plasmid-mediated B-lactamases frequently responsible for transferred drug resistance. Clavulanic acid has negligible intrisic antimicrobial activity, despite sharing the B-lactam ring that is characteristic of beta-lactam antibiotics. However, the similarity in chemical structure allows the molecule to interact with the enzyme beta-lactamase secreted by certain bacteria to confer resistance to beta-lactam antibiotics. Clavulanic acid is a suicide inhibitor, covalenty bonding to serine residue in the active site of the beta-lactamase. This restructure the clavulanic acid molecule,
creating a much more reactive species that is attacked by another amino acid in the active site permanently inactivating the enzyme. The inhibition restores the antimicrobial activity of beta-lactam .
COLISTIN SULPHATE is a member of polymyxin group of antibacterial. It acts locally in gastrointestinal tract and is a very potent agent against gram-negative bacteria.
For effective control and treatment of Salmonella Infections, Coryza, Gastrointestinal Infections and upper respiratory tract Infections.
1 gram per 2-3 liters of drinking water for 3 to 5 days.
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