Intracin Plus

COMPOSITION:

Each 1000gm Powder contains:

Enrofloxacin (HCI) 10%

Amantadine (HCI) 4%

Colistin Sulphate 3.5%

ENROFLOXACIN (antibacterial drug): A fluoroquinolone antibacterial drug; white to pale yellow crystalline powder freely soluble in water. It has a bactericidal action, inbinhibit the bacterial DNA gyrase or the topoisomerase IV enzyme, thereby inhibiting DNA replication and transcriotion Enrofloxacin effective against a broad spectrum of gram positive and gram negative bacteria, such as: Escherichia Coli, Salmonella spp, pasteurela spp, Bordetella spp, haemophillus spp and Staphylococci. COLISTIN SULPHATE (antibacterial drug): Colistin belong to polymyxin group of antibacterials. It is cationic,polypeptide antibiotic, Bacterial action; effective against gram negative micro-organisms. It penetrates in the bacterial cell membrane, change its permeability as a result of its interaction with the phospholipids component, It inhibits bacterial oxdative metbolism. AMANITADINE (Antiviral Drug): A white or almost white crystalline powder, freely soluble in water. it has pharmacological action and antiviral drug.

Amantadine inhibits the replication of viruses by interfering with the uncoating of the virus inside the cell. It as an M2 inhibitor in virus which blocks the ion channel formed by the M2 protein that spans the viral membrane. Virus enters its host cell by receptor medicated endocytosis. There after acidification of the endocytic vesicles in repuired for the dissolation of the M1 protein from the ribonucleo protein complexes. Only then are the ribonucleoprotien particles imported into the nucleus via the nuclear pores. The hydrgen ions needed for acidification pass through the M2 channel. Amantadine is absorbed 80% following oral administration and has prolonged plasma elimination half life, which average 10-14 hours. Amantadine is excreted largelely unchangecl in the urine by glomerular filtrations and tubular secretions. 

AMANTADINE is effective against both prevention and treatment of virus.

INDICATIONS: Intracin Plus is used for the treatment and prevention of bacterial infections in poultry caused by organisms sensitive to enrofloxacin and colistin; such as CRD, CCRDS,Colibacillosis ( E coli). Infectious Coryza, Fowl Cholera, Fowl Typhoid, Mycoplasmosis, Staphylococcal and Streptococcal in fections. Intracin Plus also contains Amantadine which as an antiviral agent and effective against the early

stage of dieases when viral replication is occurring.It als controls influenza, IB,NDILT,AE Fowl pox and Hydoprecardium Syndrome. DOSAGE & ADMINISTRATION. The dosage of Intracin Plus is 1 gm per2 liters of drinking water for 1-5 days or as directed by the veterinarian.

PACKING: 100gms, 500gms 1000 gms.